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| Research article summary (published 30 May 2002): |
Recovery from psychosis in schizophrenia and schizoaffective disorder: symptoms and neurocognitive rate-limiters for the development of social behavior skills.
Full Abstract
Neurocognitive deficits are believed to be important predictors of functional outcome in chronic psychotic disorders, but few supporting studies have utilized prospective designs and adequate control. The aim of this study was to estimate the relative influence of symptoms and neurocognitive deficits on the development of social behavior skills in a cohort of individuals with schizophrenia or schizoaffective disorder recovering from acute symptom exacerbations. Forty-six individuals were recruited upon discharge from an inpatient unit and completed assessments of symptoms, neurocognitive function, and social behavior at 3-month intervals for 1 year. Correlational analyses and random regression models were used to model social behavioral capacities longitudinally. Social behavior improved modestly (10% improvements in ratings) over the follow-up period for the group as a whole. Disorganized and negative symptoms, as well as neurocognitive deficits in short-term and working memory predicted changes in social behavior over time. Individuals with better working memory function showed significantly greater abilities to recover social behavior skills, whereas those with working memory deficits showed no functional improvement over time. Both symptoms and neurocognitive deficits are important determinants of functional outcome in schizophrenia. It is proposed that clinicians should consider neurocognitive thresholds for treatment response when developing rehabilitation plans.
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Author information
Author/s: Smith, Thomas E (TE); Hull, James W (JW); Huppert, Jonathan D (JD); Silverstein, Steven M (SM);
Affiliation: Department of Psychiatry, Westchester Division, Weill Medical College of Cornell University and New York-Presbyterian Hospital, 21 Bloomingdale Road, White Plains 10605, USA. tsmith(-atsign-)med.cornell.edu
Grants: MH 01359 (Agency:United States NIMH)
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Schizophrenia research (Schizophr Res), published in Netherlands. (Language: eng)
Reference: 2002-Jun; vol 55 (issue 3) : pp 229-37
Dates: Created 2002/06/05; Completed 2002/07/30; Revised 2007/11/14;
PMID: 12048146, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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