Research article summary:

Rate dependency revisited: understanding the effects of methylphenidate in children with attention deficit hyperactivity disorder.

Abstract Extract:
Although stimulants are widely prescribed for the treatment of attention deficit hyperactivity disorder (ADHD), their calming effects are not easily understood. One hypothesis derived from preclinical studies is that stimulants exert 'rate-dependent' ... (Full abstract text below)

Published 2003 in Journal: J Child Adolesc Psychopharmacol (Language : eng)

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1. J Child Adolesc Psychopharmacol. 2003 ;13(1):41-51

Rate dependency revisited: understanding the effects of methylphenidate in children with attention deficit hyperactivity disorder.

Teicher MH, Polcari A, Anderson CM, Andersen SL, Lowen SB, Navalta CP

Department of Psychiatry, Harvard Medical School, Boston, MA, USA. martin_teicher@hms.harvard.edu

Although stimulants are widely prescribed for the treatment of attention deficit hyperactivity disorder (ADHD), their calming effects are not easily understood. One hypothesis derived from preclinical studies is that stimulants exert "rate-dependent" effects that are inversely related in magnitude and direction to the baseline rate of activity or distraction. Previously, compelling support for this hypothesis has been lacking. We provide preliminary evidence that methylphenidate exerts rate-dependent behavioral effects in children with ADHD. Activity and attention were quantified in children with ADHD tested on placebo and different doses of methylphenidate using objective measures. Higher doses altered activity and attentiveness in a rate-dependent manner after correction for regression-to-the-mean artifacts. These findings illustrate a clear inverse association between symptom severity and degree of therapeutic response that is crucial for our understanding of stimulant effects and effective clinical treatment of ADHD.

PMID : 12804125 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
Martin H	Teicher	MH
Ann	Polcari	A
Carl M	Anderson	CM
Susan L	Andersen	SL
Steven B	Lowen	SB
Carryl P	Navalta	CP

Affiliation: Department of Psychiatry, Harvard Medical School, Boston, MA, USA. martin_teicher@hms.harvard.edu

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Category links from this article:

Attention - drug effects
Attention Deficit Disorder with Hyperactivity - drug therapy, psychology
Central Nervous System Stimulants - adverse effects, therapeutic use
Child
Dose-Response Relationship, Drug
Female
Humans
Male
Methylphenidate - adverse effects, therapeutic use
Treatment Outcome

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