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| Research article summary (published 30 Dec 2001): |
Quantification of corticosteroid-induced skin vasoconstriction: visual ranking, chromameter measurement or digital imaging analysis.
Full Abstract
Topical corticosteroid formulations have been evaluated by visual grading protocols for many years. Toward a more objective methodology, several instrumental methods have been evaluated for applicability in quantifying the vasoconstriction side-effect that follows corticosteroid application to the skin. Although the chromameter has been adopted by regulatory bodies throughout the world as the current standard for topical bioequivalence determinations, there is considerable criticism of this instrument from several quarters. A preliminary comparison reported here indicates that digital image analysis provides statistically significant results that are similar to those obtained by visual assessment techniques, and shows considerably greater precision than that obtained by the chromameter. Continued evaluation of objective assessment techniques, such as digital imaging, and continued modernisation of regulatory bioequivalence requirements will assist in protecting patients and optimising clinical results.Copyright 2002 S. Karger AG, Basel
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Author information
Author/s: Smith, E W (EW); Haigh, J M (JM); Surber, C (C);
Affiliation: College of Pharmacy, Ohio Northern University, Ada 45810, USA. e-smith3@onu.edu
Journal and publication information
Publication Type: Comparative Study; Journal Article
Journal: Dermatology (Basel, Switzerland) (Dermatology), published in Switzerland. (Language: eng)
Reference: 2002-; vol 205 (issue 1) : pp 3-10
Dates: Created 2002/07/29; Completed 2002/10/03; Revised 2006/11/15;
PMID: 12145427, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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