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| Research article summary (published 27 Feb 2003): |
Proton magnetic resonance spectroscopy investigation of the right frontal lobe in children with attention-deficit/hyperactivity disorder.
Full Abstract
OBJECTIVE:
To investigate neurometabolite concentrations in right prefrontal white matter in children with attention-deficit/hyperactivity disorder (ADHD) and relations of neurometabolites with attention skill and frontal anatomy.
METHOD:
Single voxel proton magnetic resonance spectroscopy ( H-MRS), quantitative morphometric analysis of left and right dorsolateral frontal volumes, and assessment of attentional problems with the Conners Continuous Performance Test were undertaken in 23 children (17 male) with ADHD (with no comorbid learning disabilities) and 24 matched controls (16 male).
RESULTS:
No overall group differences were found for any neurometabolite. However, a group by sex interaction was noted for -acetylaspartate, such that girls with ADHD had especially low concentrations. Morphological analyses revealed smaller right (but not left) dorsolateral volumes in children with ADHD, and in the ADHD group this volume correlated with neurometabolite concentrations. In the ADHD group Continuous Performance Test performance was related to both dorsolateral volume and the creatine-phosphocreatine peak from H-MRS.
CONCLUSIONS:
These results add to a growing body of evidence suggesting sex-specific neurobiological differences in ADHD and draw attention to relationships between neurochemistry, neuroanatomy, and performance in children with ADHD. Study limitations include small sample size and clinical heterogeneity among the children with ADHD.
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Author information
Author/s: Yeo, Ronald A (RA); Hill, Dina E (DE); Campbell, Richard A (RA); Vigil, Janet (J); Petropoulos, Helen (H); Hart, Blaine (B); Zamora, Leona (L); Brooks, William M (WM);
Affiliation: University of New Mexico, Albuquerque, USA. ryeo(-atsign-)unm.edu
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Journal of the American Academy of Child and Adolescent Psychiatry (J Am Acad Child Adolesc Psychiatry), published in United States. (Language: eng)
Reference: 2003-Mar; vol 42 (issue 3) : pp 303-10
Dates: Created 2003/02/21; Completed 2003/04/23; Revised 2006/11/15;
PMID: 12595783, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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