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| Research article summary (published 30 Aug 2002): |
Proton magnetic resonance spectroscopy of the hippocampus and occipital white matter in PTSD: preliminary results.
Full Abstract
OBJECTIVE:
Previous proton magnetic resonance spectroscopy (1H-MRS) studies in posttraumatic stress disorder (PTSD) report decreased hippocampal N-acetylaspartate (NAA), an indicator of neuronal integrity. However, other areas of the brain need to be explored. The objective of this study was to investigate the specificity of hippocampal NAA concentration changes in PTSD by also examining a control region, the occipital white matter (OWM).
METHODS:
Eight patients with PTSD and 5 control subjects underwent single-voxel 1H-MRS of the hippocampi and bilateral OWM. Absolute neurometabolite concentrations were determined.
PRELIMINARY RESULTS:
Trends toward reduced left hippocampal NAA and creatine (Cre) were found in the PTSD group. PTSD subjects also had reduced bilateral OWM Cre.
CONCLUSIONS:
The preliminary results of our study in civilians with PTSD replicate previous MRS studies and are consistent with decreased hippocampal neuronal integrity without effects in the OWM. Replication of our findings is needed.
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Author information
Author/s: Villarreal, Gerardo (G); Petropoulos, Helen (H); Hamilton, Derek A (DA); Rowland, Laura M (LM); Horan, William P (WP); Griego, Jacqueline A (JA); Moreshead, Margaret (M); Hart, Blaine L (BL); Brooks, William M (WM);
Affiliation: PTSD Clinic, Veterans Administration Hospital, Departments of Psychiatry and Neurosciences, University of New Mexico, Albuquerque, New Mexico, USA. gerardo.villarreal(-atsign-)med.va.gov
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie (Can J Psychiatry), published in Canada. (Language: eng)
Reference: 2002-Sep; vol 47 (issue 7) : pp 666-70
Dates: Created 2002/10/01; Completed 2002/10/29; Revised 2007/08/01;
PMID: 12355679, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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