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| Research article summary (published 17 Mar 2003): |
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Prospective study of alcohol consumption and risk of dementia in older adults.
Full Abstract
CONTEXT:
Alcohol consumption has been associated with complex changes in cerebral vasculature and structure in older adults. How alcohol consumption affects the incidence of dementia is less clear.
OBJECTIVE:
To determine the prospective relationship of alcohol consumption and risk of dementia among older adults. DESIGN, SETTING,
AND PARTICIPANTS:
Nested case-control study of 373 cases with incident dementia and 373 controls who were among 5888 adults aged 65 years and older who participated in the Cardiovascular Health Study, a prospective, population-based cohort study in 4 US communities. The controls were frequency-matched on age, death before 1999, and their attendance of a 1998-1999 clinic. Participants in this study underwent magnetic resonance imaging (MRI) of the brain and cognitive testing between 1992 and 1994 and were followed up until 1999.
MAIN OUTCOME MEASURES:
Odds of incident dementia, ascertained by detailed neurological and neuropsychological examinations according to average alcohol consumption, assessed by self-reported intake of beer, wine, and liquor at 2 visits prior to the date of the MRI.
RESULTS:
Compared with abstention, the adjusted odds for dementia among those whose weekly alcohol consumption was less than 1 drink were 0.65 (95% confidence interval [CI], 0.41-1.02); 1 to 6 drinks, 0.46 (95% CI, 0.27-0.77); 7 to 13 drinks, 0.69 (95% CI, 0.37-1.31); and 14 or more drinks, 1.22 (95% CI, 0.60-2.49; P for quadratic term =.001). A trend toward greater odds of dementia associated with heavier alcohol consumption was most apparent among men and participants with an apolipoprotein E epsilon4 allele. We found generally similar relationships of alcohol use with Alzheimer disease and vascular dementia.
CONCLUSIONS:
Compared with abstention, consumption of 1 to 6 drinks weekly is associated with a lower risk of incident dementia among older adults.
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Author information
Author/s: Mukamal, Kenneth J (KJ); Kuller, Lewis H (LH); Fitzpatrick, Annette L (AL); Longstreth, W T (WT); Mittleman, Murray A (MA); Siscovick, David S (DS);
Affiliation: Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Ave, RO-114, Boston, Mass 02215, USA. kmukamal(-atsign-)caregroup.harvard.edu
Grants: K23AA00299 (Agency:United States NIAAA) ; N01HC15103 (Agency:United States NHLBI) ; N01HC85079 (Agency:United States NHLBI) ; N01HC85080 (Agency:United States NHLBI) ; N01HC85081 (Agency:United States NHLBI) ; N01HC85082 (Agency:United States NHLBI) ; N01HC85083 (Agency:United States NHLBI) ; N01HC85084 (Agency:United States NHLBI) ; N01HC85085 (Agency:United States NHLBI) ; N01HC85086 (Agency:United States NHLBI) ; R01AG015928 (Agency:United States NIA)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: JAMA : the journal of the American Medical Association (JAMA), published in United States. (Language: eng)
Reference: 2003-Mar; vol 289 (issue 11) : pp 1405-13
Dates: Created 2003/03/14; Completed 2003/04/03; Revised 2007/11/14;
PMID: 12636463, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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