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| Research article summary (published 27 Feb 2002): |
Procedural learning and striatofrontal dysfunction in Parkinson's disease.
Full Abstract
The neural basis of procedural learning remains controversial. We further analyzed procedural learning in nondemented patients with Parkinson's disease (PD) according to the specific demands of the tasks and the severity of striatal and frontal lobe dysfunction. In the first experiment, the performance of 20 nondemented PD patients and matched normal control subjects was studied in two procedural learning tasks, rotor pursuit and mirror reading, that differ in terms of motor and cognitive involvement. A second experiment further assessed the relationship between learning in mirror reading and executive functions in a new group of 15 nondemented PD patients. In rotor pursuit, PD patients significantly progressed across the first sessions, although their asymptotic performance was inferior to that of controls. In mirror reading, both experiments showed substantial learning in PD patients considered as a group. However, subsequent analyses allowed us to distinguish PD patients without executive dysfunction, whose learning was normal, from PD patients with executive dysfunction, whose learning was severely impaired. These results confirm the involvement of striatofrontal circuits in procedural learning and indicate that the intervention of the frontal network may depend on the characteristics of the task.Copyright 2002 Movement Disorder Society.
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Author information
Author/s: Sarazin, Marie (M); Deweer, Bernard (B); Merkl, Angela (A); Von Poser, Natalia (N); Pillon, Bernard (B); Dubois, Bruno (B);
Affiliation: Institut National de la Santé et de la Recherche Médicale E 007, Paris, France.
Journal and publication information
Publication Type: Journal Article
Journal: Movement disorders : official journal of the Movement Disorder Society (Mov Disord), published in United States. (Language: eng)
Reference: 2002-Mar; vol 17 (issue 2) : pp 265-73
Dates: Created 2002/03/28; Completed 2002/05/17; Revised 2004/11/17;
PMID: 11921111, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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