Research article summary:

Procedural learning in schizophrenia: a functional magnetic resonance imaging investigation.

Abstract Extract:
Procedural learning (PL) is a type of rule-based learning in which performance facilitation occurs with practice on task without the need for conscious awareness. Schizophrenic patients have often (though not invariably) been found to show impaired PL. ... (Full abstract text below)

Published 2002Sep in Journal: Schizophr Res (Language : eng)

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1. Schizophr Res. 2002 Sep;57(1):97-107

Procedural learning in schizophrenia: a functional magnetic resonance imaging investigation.

Kumari V, Gray JA, Honey GD, Soni W, Bullmore ET, Williams SC, Ng VW, Vythelingum GN, Simmons A, Suckling J, Corr PJ, Sharma T

Section of Cognitive Psychopharmacology, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK. v.kumari@iop.kcl.ac.uk

Procedural learning (PL) is a type of rule-based learning in which performance facilitation occurs with practice on task without the need for conscious awareness. Schizophrenic patients have often (though not invariably) been found to show impaired PL. We performed functional magnetic resonance imaging (fMRI) during a blocked, periodic sequence-learning task with groups of: (i) healthy subjects, and (ii) schizophrenic patients on conventional antipsychotics. Healthy subjects showed significant PL, but patients did not. In healthy subjects, PL was associated with increased activation in the striatum, thalamus, cerebellum, precuneus, medial frontal lobe, and cingulate gyrus. The power of activation in the thalamus, striatum, precuneus, cingulate gyrus and BA 6 was related to the magnitude of PL in these subjects. No regions, except the anterior inferior gyrus, were significantly activated in patients. The caudate nucleus, thalamus, precuneus, and sensorimotor regions were activated significantly differently between the two groups. The findings demonstrate the involvement of the striatum, cerebellum, thalamus, cingulate gyrus, precuneus, and sensorimotor regions in PL. Further fMRI studies of PL in normal subjects treated with conventional antipsychotics, drug naïve patients, and patients given atypical antipsychotics would help to clarify the roles of schizophrenic disease processes and antipsychotic medication in impaired PL and associated brain abnormalities in schizophrenia.

PMID : 12165380 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
Veena	Kumari	V
Jeffrey A	Gray	JA
Garry D	Honey	GD
William	Soni	W
Edward T	Bullmore	ET
Steven C R	Williams	SC
Virginia Wk	Ng	VW
Goparlen N	Vythelingum	GN
Andrew	Simmons	A
John	Suckling	J
Philip J	Corr	PJ
Tonmoy	Sharma	T

Affiliation: Section of Cognitive Psychopharmacology, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK. v.kumari@iop.kcl.ac.uk

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