Prefrontal cortex contribution to associative recognition memory in humans: an event-related functional magnetic resonance imaging study.

Full Abstract

The present event-related fMRI study examined in ten healthy participants neural correlates of recognition memory for intact, rearranged, and new pairs of visual stimuli. The correct categorization of both intact and rearranged pairs relative to pairs of new, never presented before stimuli relies on the retrieval of associative information whereas the discrimination of rearranged pairs from intact pairs additionally involves a recall-to-reject process by which subjects retrieve additional information to reach a recognition decision. Relative to new pairs, both intact and rearranged pairs yielded activation in inferior prefrontal cortex bilaterally and left dorsolateral prefrontal cortex. Relative to intact pairs, rearranged pairs were associated with increased activity in left dorsolateral prefrontal cortex. The latter could reflect the neural correlates of a recall-to-reject process, a pivotal process of associative recognition memory.

Learn Faster Today Improve your study skills

Author information

Author/s: Lepage, Martin (M); Brodeur, Mathieu (M); Bourgouin, Pierre (P);

Affiliation: Brain Imaging Group, Douglas Hospital Research Centre, Quebec, Verdun, Canada. martin.lepage(-atsign-)mcgill.ca

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuroscience letters (Neurosci Lett), published in Ireland. (Language: eng)

Reference: 2003-Jul; vol 346 (issue 1-2) : pp 73-6

Dates: Created 2003/07/09; Completed 2003/09/02; Revised 2006/11/15;

PMID: 12850551, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Evoked Potentials - physiology
Female
Humans
Magnetic Resonance Imaging - methods

Magnetic Resonance Imaging - methods
Male
Photic Stimulation - methods
Prefrontal Cortex - physiology
Recognition (Psychology) - physiology

These are the highest related articles currently in the database:

See 100+ related articles.