Predicting the practice effects on the blood oxygenation level-dependent (BOLD) function of fMRI in a symbolic manipulation task.

Full Abstract

Based on adaptive control of thought-rational (ACT-R), a cognitive architecture for cognitive modeling, researchers have developed an information-processing model to predict the blood oxygenation level-dependent (BOLD) response of functional MRI in symbol manipulation tasks. As an extension of this research, the current event-related functional MRI study investigates the effect of relatively extensive practice on the activation patterns of related brain regions. The task involved performing transformations on equations in an artificial algebra system. This paper shows that the base-level activation learning in the ACT-R theory can predict the change of the BOLD response in practice in a left prefrontal region reflecting retrieval of information. In contrast, practice has relatively little effect on the form of BOLD response in the parietal region reflecting imagined transformations to the equation or the motor region reflecting manual programming.

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Author information

Author/s: Qin, Yulin (Y); Sohn, Myeong-Ho (MH); Anderson, John R (JR); Stenger, V Andrew (VA); Fissell, Kate (K); Goode, Adam (A); Carter, Cameron S (CS);

Affiliation: Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA. yulinq(-atsign-)cmu.edu

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), published in United States. (Language: eng)

Reference: 2003-Apr; vol 100 (issue 8) : pp 4951-6

Dates: Created 2003/04/16; Completed 2003/06/17; Revised 2008/11/20;

PMID: 12672965, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Brain - anatomy & histology; physiology
Cognition - physiology
Female
Humans
Learning - physiology
Magnetic Resonance Imaging

Magnetic Resonance Imaging
Male
Models, Neurological
Models, Psychological
Oxygen - blood
Parietal Lobe - physiology
Prefrontal Cortex - physiology

Associated Chemicals: Oxygen (7782-44-7)

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