Pramipexole in comparison to l-dopa: a neuropsychological study.

Full Abstract

Twenty right-handed patients affected by early/mild Parkinson's disease were evaluated in a randomised study using neuropsychological and clinical assessements during three treatment modalities:
when in the off treatment condition, when on pramipexole, and when on l-dopa. In comparison to the off treatment condition, the DA-agonist pramipexole produced a significant impairment of short term verbal memory, attentional-executive functions and verbal fluency, while l-dopa did not. Moreover, pramipexole opposite to l-dopa, failed to improve FAS and Stroop tests. Present findings indicate that pramipexole may worsen cognitive functions although not exceeding normative values.

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Author information

Author/s: Brusa, L (L); Bassi, A (A); Stefani, A (A); Pierantozzi, M (M); Peppe, A (A); Caramia, M D (MD); Boffa, L (L); Ruggieri, S (S); Stanzione, P (P);

Affiliation: IRCCS Fondazione S. Lucia.

Journal and publication information

Publication Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial

Journal: Journal of neural transmission (Vienna, Austria : 1996) (J Neural Transm), published in Austria. (Language: eng)

Reference: 2003-Apr; vol 110 (issue 4) : pp 373-80

Dates: Created 2003/03/26; Completed 2003/08/08; Revised 2006/11/15;

PMID: 12658365, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged
Analysis of Variance
Benzothiazoles
Cognition Disorders - chemically induced; psychology
Female
Humans

Levodopa - adverse effects; therapeutic use
Male
Middle Aged
Neuropsychological Tests - statistics & numerical data
Parkinson Disease - drug therapy; psychology
Thiazoles - adverse effects; therapeutic use

Associated Chemicals: Benzothiazoles (0) ; Levodopa (0) ; Thiazoles (0) ; pramipexol (104632-26-0)

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