Possible association between serotonin transporter promoter region polymorphism and impulsivity in Koreans.

Full Abstract

Serotonin has become the major focus of biological studies of suicidal behavior and impulsive-aggressive behavior in humans. The serotonin transporter (5-HTT) gene is one of the important genes involved in the regulation of serotonin transmission. We examined the association of impulsivity in Korean populations with a functional polymorphism of the promoter region of the 5-HTT gene (5-HTTLPR). We recruited 186 adolescent prisoners and 64 medical students. Impulsivity was measured using the Barratt Impulsiveness Scale and we divided all subjects into three groups:
impulsive subjects (IS, N=121), non-impulsive subjects (NIS, N=115) and an intermediate group (excluded, N=14). The 5-HTTLPR genotype was determined by polymerase chain reaction. All subjects were Korean men unrelated to each other. There were no significant differences in the genotype frequency of 5-HTTLPR-S/S, S/L and -L/L between the two groups in the Korean population (IS vs.

NIS:
47.9 vs. 61.7%; 43.0 vs. 32.2%; and 9.1 vs. 6.1%, respectively). However, there was a statistically significant difference in allelic frequency of 5-HTTLPR-S and 5-HTTLPR-L between the two groups in the Korean population (IS vs.

NIS:
69.4 vs. 77.8%; and 30.6 vs. 22.2%, respectively. From our results, this 5-HTTLPR polymorphism appears to be a possible candidate gene for impulsivity in the Korean population.

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Author information

Author/s: Lee, Jong-Hun (JH); Kim, Hong-Tae (HT); Hyun, Dae-Sung (DS);

Affiliation: Department of Psychiatry, School of Medicine, Catholic University of Daegu, Nam-Gu, South Korea. rheejh(-atsign-)cataegu.ac.kr

Journal and publication information

Publication Type: Journal Article

Journal: Psychiatry research (Psychiatry Res), published in Ireland. (Language: eng)

Reference: 2003-May; vol 118 (issue 1) : pp 19-24

Dates: Created 2003/05/21; Completed 2003/10/03; Revised 2008/11/21;

PMID: 12759157, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Carrier Proteins - genetics
DNA Primers - genetics
Genotype
Humans
Impulse Control Disorders - ethnology; genetics; psychology
Korea
Membrane Glycoproteins - genetics

Membrane Glycoproteins - genetics
Membrane Transport Proteins
Nerve Tissue Proteins
Polymerase Chain Reaction
Polymorphism, Genetic - genetics
Prisoners - psychology
Promoter Regions, Genetic - genetics
Serotonin Plasma Membrane Transport Proteins
Students - psychology

Associated Chemicals: Carrier Proteins (0) ; DNA Primers (0) ; Membrane Glycoproteins (0) ; Membrane Transport Proteins (0) ; Nerve Tissue Proteins (0) ; SLC6A4 protein, human (0) ; Serotonin Plasma Membrane Transport Proteins (0)

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