Positive and negative schizotypy in a student sample: neurocognitive and clinical correlates.

Full Abstract

Positive and negative schizotypy may represent discrete factors or dimensions. To determine if distinct neurocognitive profiles are associated with these dimensions or factors, we classified university students on the basis of positive and negative schizotypal symptoms and conducted separate analyses. Following prior work in the neuropsychiatric literature, we predicted that subtle prefrontal deficits would be selectively associated with negative schizotypal personality features in a nonclinical student sample. We also investigated the relationship between positive/negative schizotypy and associated clinical states or personality dimensions including antisocial personality disorder, obsessive-compulsive personality traits, generalized and social anxiety, empathy, and impulsivity. Classification of subjects into positive and negative schizotypy groups revealed distinct neurocognitive and clinical profiles. We observed a positive relation between measures of temporolimbic dysfunction, impulsivity, antisocial behavior, and positive schizotypal phenomena. Negative schizotypy was associated with subtle performance deficits on measures of frontal executive function, increased social anxiety, and obsessive-compulsive phenomena. Findings are consistent with the contention that positive and negative schizotypy represent discrete factors.

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Author information

Author/s: Dinn, Wayne M (WM); Harris, Catherine L (CL); Aycicegi, Ayse (A); Greene, Paul (P); Andover, Margaret S (MS);

Affiliation: Department of Psychology, Boston University, Boston, MA, USA. dinn(-atsign-)bu.edu

Journal and publication information

Publication Type: Journal Article

Journal: Schizophrenia research (Schizophr Res), published in Netherlands. (Language: eng)

Reference: 2002-Jul; vol 56 (issue 1-2) : pp 171-85

Dates: Created 2002/06/26; Completed 2002/07/31; Revised 2004/11/17;

PMID: 12084431, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Antisocial Personality Disorder - diagnosis; physiopathology; psychology
Cognition Disorders - diagnosis; physiopathology; psychology
Comorbidity
Empathy
Female
Humans
Impulsive Behavior - diagnosis; physiopathology; psychology
Limbic System - physiopathology

Limbic System - physiopathology
Male
Neuropsychological Tests - statistics & numerical data
Obsessive-Compulsive Disorder - diagnosis; physiopathology; psychology
Personality Inventory - statistics & numerical data
Prefrontal Cortex - physiopathology
Psychometrics
Schizotypal Personality Disorder - diagnosis; physiopathology; psychology
Students - psychology
Temporal Lobe - physiopathology

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