Participation of CaMKII in neuronal plasticity and memory formation.

Full Abstract

1. The unique biochemical properties of Ca(2+)/calmodulin (CaM)-dependent protein kinase II have made this enzyme one of the paradigmatic models of the forever searched "memory molecule." 2. In particular, the central participation of CaMKII as a sensor of the Ca(2+) signals generated by activation of NMDA receptors after the induction of long-term plastic changes, has encouraged the use of pharmacological, genetic, biochemical, and imaging tools to unveil the role of this kinase in the acquisition, consolidation, and expression of different types of memories. 3. Here we review some of the more exciting discoveries related to the mechanisms involved in CaMKII activation and synaptic plasticity.

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Author information

Author/s: Cammarota, Martín (M); Bevilaqua, Lia R M (LR); Viola, Haydée (H); Kerr, Daniel S (DS); Reichmann, Bruno (B); Teixeira, Viviane (V); Bulla, Mário (M); Izquierdo, Iván (I); Medina, Jorge H (JH);

Affiliation: Centro de Memória, Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, Brasil. mcammaro(-atsign-)terra.com.br

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: Cellular and molecular neurobiology (Cell Mol Neurobiol), published in United States. (Language: eng)

Reference: 2002-Jun; vol 22 (issue 3) : pp 259-67

Dates: Created 2002/12/09; Completed 2003/01/08; Revised 2007/11/15;

PMID: 12469869, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Calcium Signaling - physiology
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases - metabolism
Hippocampus - cytology; enzymology
Humans

Memory - physiology
Neuronal Plasticity - physiology
Presynaptic Terminals - enzymology; ultrastructure
Receptors, Glutamate - metabolism
Synaptic Membranes - metabolism
Synaptic Transmission - physiology

Associated Chemicals: Receptors, Glutamate (0) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Calcium-Calmodulin-Dependent Protein Kinases (EC 2.7.11.17)

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