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Research article summary:
Overactive action monitoring in obsessive-compulsive disorder: evidence from functional magnetic resonance imaging.
Abstract Extract:
The anterior cingulate cortex (ACC) in patients with obsessive-compulsive disorder (OCD) has been found to be hyperactive at rest, during symptom provocation, and after commission of errors in cognitive tasks. This hyperactivity might reflect an ... (Full abstract text below) Published 2003Jul
in Journal: Psychol Sci
(Language : eng)
Full Pubmed Extract
This information was retrieved, real-time, on your behalf from the public area of the Pubmed website:
1. Psychol Sci.
2003 Jul;14(4):347-53
Overactive action monitoring in obsessive-compulsive disorder: evidence from functional magnetic resonance imaging.
Ursu S, Stenger VA, Shear MK, Jones MR, Carter CS
Department of Neuroscience, University of Pittsburgh, USA.
The anterior cingulate cortex (ACC) in patients with obsessive-compulsive disorder (OCD) has been found to be hyperactive at rest, during symptom provocation, and after commission of errors in cognitive tasks. This hyperactivity might reflect an abnormality in conflict detection, a hypothesized basic mechanism for the action-monitoring function of the ACC. This hypothesis was tested using functional magnetic resonance imaging, by scanning 11 OCD patients and 13 matched control subjects while they performed a version of the continuous-performance task with four trial types that induced graded levels of response conflict. Although a behavioral index of conflict (i.e., accuracy) was similar for patients and control subjects, the ACC activation was increased in patients during high-conflict trials. The error-related activity in the same brain region was also higher in patients, consistent with previous electrophysiological findings. Both conflict- and error-related activity showed trends for positive correlations with severity of OCD symptoms, but not with anxiety. These findings suggest that as part of an overactive action-monitoring system, the ACC is more directly involved in the pathophysiology of OCD than previously thought.
PMID : 12807408 [PubMed - Indexed for MEDLINE]
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Full Author Information
| First Name | LastName | Initials |
| Stefan | Ursu | S |
| V Andrew | Stenger | VA |
| M Katherine | Shear | MK |
| Mark R | Jones | MR |
| Cameron S | Carter | CS |
Affiliation: Department of Neuroscience, University of Pittsburgh, USA.
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MESH categories and related page links
This article was linked to the MESH categories shown on the left below. The links on the right are related Memletics pages.
Category links from this article:- Adult
- Arousal - physiology
- Attention - physiology
- Brain Mapping
- Cognitive Dissonance
- Female
- Gyrus Cinguli - physiopathology
- Humans
- Image Processing, Computer-Assisted
- Imaging, Three-Dimensional
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Obsessive-Compulsive Disorder - diagnosis, physiopathology
- Oxygen Consumption - physiology
- Psychomotor Performance - physiology
- Reaction Time - physiology
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