Research article summary:

Orienting of attention and Parkinsons disease: tactile inhibition of return and response inhibition.

Abstract Extract:
There is growing evidence for cognitive impairments in Parkinsons disease (PD), including in the orienting of attention and inhibition of return (IOR). IOR refers to the slowing of a response to a target stimulus presented in the same location as a ... (Full abstract text below)

Published 2003Sep in Journal: Brain (Language : eng)

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1. Brain. 2003 Sep;126(Pt 9):2081-92

Orienting of attention and Parkinson's disease: tactile inhibition of return and response inhibition.

Poliakoff E, O'Boyle DJ, Moore AP, McGlone FP, Cody FW, Spence C

School of Biological Sciences, The University of Manchester, Oxford Road, Manchester M13 9PL, UK. Ellen@Poliakoff.org.uk

There is growing evidence for cognitive impairments in Parkinson's disease (PD), including in the orienting of attention and inhibition of return (IOR). IOR refers to the slowing of a response to a target stimulus presented in the same location as a previous stimulus. While some researchers have reported normal levels of visual IOR in PD patients using cue-target tasks, others have reported significant reductions in IOR in this patient group. However, the inhibitory effects observed in cue-target tasks may reflect non-ocular response inhibition associated with withholding a response from the cue stimulus, rather than attentional or oculomotor processes. Many researchers working with normal participants have circumvented this confound by using a target-target task, in which a response is made to all peripheral stimuli. Here, we compared IOR measured in cue-target and target-target tasks, using tactile rather than visual stimuli. Both the PD and the control groups exhibited significant inhibitory effects in the cue-target task, but only the control group exhibited significant IOR in the target-target task. Our results demonstrate a reduction, or elimination, of IOR in PD and this change may have been underestimated in previous studies, in which methodologically flawed cue-target tasks were used. This reduction in IOR may reflect impaired inhibitory processes or hyper-reflexive orienting in parkinsonian patients.

PMID : 12876143 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
Ellen	Poliakoff	E
Donald J	O'Boyle	DJ
A Peter	Moore	AP
Francis P	McGlone	FP
Frederick W J	Cody	FW
Charles	Spence	C

Affiliation: School of Biological Sciences, The University of Manchester, Oxford Road, Manchester M13 9PL, UK. Ellen@Poliakoff.org.uk

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