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Research article summary:
Novelty responses and differential effects of order in the amygdala, substantia innominata, and inferior temporal cortex.
Abstract Extract:
Recent studies of amygdala function have focused on examining responses to emotionally valenced versus neutral stimuli. However, electrophysiologic and neuroimaging studies also suggest that novel neutral faces activate the amygdala, though few ... (Full abstract text below) Published 2003Mar
in Journal: Neuroimage
(Language : eng)
Full Pubmed Extract
This information was retrieved, real-time, on your behalf from the public area of the Pubmed website:
1. Neuroimage.
2003 Mar;18(3):660-9
Novelty responses and differential effects of order in the amygdala, substantia innominata, and inferior temporal cortex.
Wright CI, Martis B, Schwartz CE, Shin LM, Fischer H H, McMullin K, Rauch SL
Psychiatric Neuroimaging Research Group, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY-9, Charlestown, MA 02129, USA. ciwright@partners.org
Recent studies of amygdala function have focused on examining responses to emotionally valenced versus neutral stimuli. However, electrophysiologic and neuroimaging studies also suggest that novel neutral faces activate the amygdala, though few investigations have examined the effects of novelty and its relation to changes in stimulus condition. To further investigate how the human amygdala and related structures react to novel neutral faces and to stimulus condition changes, we evaluated human brain responses to blocks containing multiple novel and single repeated face stimuli, presented in two different orders, using functional magnetic resonance imaging (fMRI). Significantly increased signal was present in the amygdala, substantia innominata (SI), and inferior temporal cortex (ITC) to the contrast of multiple novel versus single faces. However, these regions differed in their responses based on whether a stimulus condition was presented 1st or 2nd, with the amygdala and SI having significantly different response profiles than the ITC. Specifically, greater responses to stimuli presented 2nd (i.e., after a condition change) were found in the amygdala and SI, but not in the ITC. Furthermore, the response difference to the Multiple versus Single contrast was greatest in the amygdala and SI, when single faces were presented 1st, and multiple faces presented 2nd, but this pattern was the reverse in the ITC. We speculate that the signal changes to neutral faces in the amygdala and SI with respect to condition (multiple or single faces) and stimulus order may relate to the involvement of these structures in novelty detection and the orienting response.
PMID : 12667843 [PubMed - Indexed for MEDLINE]
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Full Author Information
| First Name | LastName | Initials |
| Christopher I | Wright | CI |
| Brian | Martis | B |
| Carl E | Schwartz | CE |
| Lisa M | Shin | LM |
| Håkan | Fischer H | H |
| Katherine | McMullin | K |
| Scott L | Rauch | SL |
Affiliation: Psychiatric Neuroimaging Research Group, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY-9, Charlestown, MA 02129, USA. ciwright@partners.org
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MESH categories and related page links
This article was linked to the MESH categories shown on the left below. The links on the right are related Memletics pages.
Category links from this article:- Adult
- Amygdala - physiology
- Arousal - physiology
- Attention - physiology
- Brain Mapping
- Echo-Planar Imaging
- Emotions - physiology
- Facial Expression
- Female
- Humans
- Image Processing, Computer-Assisted
- Imaging, Three-Dimensional
- Magnetic Resonance Imaging
- Male
- Memory, Short-Term - physiology
- Orientation - physiology
- Pattern Recognition, Visual - physiology
- Serial Learning - physiology
- Substantia Innominata - physiology
- Temporal Lobe - physiology
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