 |
| Research article summary (published 30 Dec 2001): |
Novelty-related activation within the medial temporal lobes.
Full Abstract
Functional magnetic resonance imaging (fMRI) was used to examine whether (1) verbal associative encoding activates the medial temporal lobes (MTL) and related regions more than non-associative encoding, (2) verbal associative novelty is related to enhanced MTL activation, and (3) verbal item novelty is related to enhanced MTL activation and, if so, whether these activations are in different or overlapping sites. No increase in MTL activation was found during verbal associative encoding relative to non-associative encoding, although associative encoding was related to a relative increase in activation in the posterior cingulate cortex. In contrast, verbal associative novelty was found to activate the MTL and posterior cingulate cortex. Verbal item novelty did not significantly activate any brain region. The verbal associative novelty-related effect occurred despite subjects having little awareness of associative novelty. The verbal associative novelty-related activation in the MTL may be related either to unconscious novelty detection or to a priming effect at encoding. We argue that if the priming explanation is correct then this may account for our failure to observe an associative encoding MTL activation.
Learn Faster Today Improve your study skills
Author information
Author/s: Hunkin, Nicola M (NM); Mayes, Andrew R (AR); Gregory, Lloyd J (LJ); Nicholas, Amanda K (AK); Nunn, Julia A (JA); Brammer, Michael J (MJ); Bullmore, Edward T (ET); Williams, Steve C R (SC);
Affiliation: Academic Neurology Unit, Royal Hallamshire Hospital, University of Sheffield, UK. n.m.hunkin(-atsign-)sheffield.ac.uk
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Neuropsychologia (Neuropsychologia), published in England. (Language: eng)
Reference: 2002-; vol 40 (issue 8) : pp 1456-64
Dates: Created 2002/04/04; Completed 2002/09/03; Revised 2006/11/15;
PMID: 11931949, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.