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| Research article summary (published 30 Mar 2003): |
NOTCH4 and the frontal lobe in schizophrenia.
Full Abstract
NOTCH4 is a developmentally expressed gene recently reported to be in linkage disequilibrium (LD) with schizophrenia. We investigated this finding in our sample of subjects, focusing on an exonic (CTG)(n) polymorphism, examining not only the association of this polymorphism with the disease phenotype, but also its effect on frontal lobe brain morphology and cognitive function in both affected individuals and a psychiatrically normal comparison group. While we did not find any association or LD with schizophrenia, we identified striking effects of NOTCH4 variability on the trait measures. Within the respective schizophrenia and comparison groups, NOTCH4 allelic variability was correlated with differences in measures of frontal lobe cognitive performance and frontal lobe brain tissue volumes that were intuitively congruent. These within-group effects, however, were in opposite directions across groups. These findings may reflect the interaction of NOTCH4 with the underlying genetic and phenotypic complexity that characterizes both schizophrenia and normal cognition and brain development.Copyright 2003 Wiley-Liss, Inc.
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Author information
Author/s: Wassink, Thomas H (TH); Nopoulos, Peggy (P); Pietila, Jennifer (J); Crowe, Raymond R (RR); Andreasen, Nancy C (NC);
Affiliation: Department of Psychiatry, Psychiatry Research/MEB, University of Iowa College of Medicine, Iowa City, IA 52242, USA. thomas-wassink(-atsign-)uiowa.edu.
Grants: MH 00735 (Agency:United States NIMH) ; MH 31593 (Agency:United States NIMH) ; MH 40856 (Agency:United States NIMH) ; MH 43212 (Agency:United States NIMH) ; MH 43271 (Agency:United States NIMH)
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet), published in United States. (Language: eng)
Reference: 2003-Apr; vol 118B (issue 1) : pp 1-7
Dates: Created 2003/03/10; Completed 2003/07/14; Revised 2008/05/21;
PMID: 12627456, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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