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Research article summary:
Normal pressure hydrocephalus triggers intrathecal production of TNF-alpha.
Abstract Extract:
Normal pressure hydrocephalus (NPH) is associated with periventricular white matter lesions and demyelination. The aim of the present study was to examine the cerebrospinal fluid (CSF) levels of tumor necrosis factor-alpha (TNF-alpha), a proinflammatory ... (Full abstract text below) Published 2003Sep
in Journal: Neurobiol Aging
(Language : eng)
Full Pubmed Extract
This information was retrieved, real-time, on your behalf from the public area of the Pubmed website:
1. Neurobiol Aging.
2003 Sep;24(5):707-14
Normal pressure hydrocephalus triggers intrathecal production of TNF-alpha.
Tarkowski E, Tullberg M, Fredman P, Wikkelsö C
Department of Rheumatology and Neurology, University of Göteborg, Guldhedsgatan 10, S-413 46, Göteborg, Sweden. elisabeth.tarkowski@immuno.gu.se
Normal pressure hydrocephalus (NPH) is associated with periventricular white matter lesions and demyelination. The aim of the present study was to examine the cerebrospinal fluid (CSF) levels of tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine mediating myelin damage, in patients with NPH. TNF-alpha levels were analyzed by ELISA and measured before and after shunt operation in 35 patients with NPH. The levels of this cytokine were related to the symptomatology and to magnetic resonance imaging (MRI) verified white matter lesions. They were also related to intrathecal levels of sulfatide, a marker for white matter degradation and to levels of neurofilament, a marker for neuronal degeneration.The preoperative levels of TNF-alpha were increased in the CSF of NPH patients compared to controls, and correlated to the levels of sulfatide. The intrathecal TNF-alpha levels were higher in NPH patients with impairment of wakefulness than in those without this symptom. The preoperative TNF-alpha levels were significantly correlated to the improvement of psychometrical test scores, and of wakefulness and to the overall improvement of the patients following shunt operation. Importantly, shunt operation led to complete disappearance of intrathecal TNF-alpha. We conclude that NPH is correlated with intrathecal TNF-alpha production being reversed following shunt operation in parallel with the clinical improvement. The positive correlation between preoperative TNF-alpha and sulfatide levels in the CSF suggest that intrathecal TNF-alpha may contribute to the damage of the white matter known to occur in patients with NPH.
PMID : 12885578 [PubMed - Indexed for MEDLINE]
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Full Author Information
| First Name | LastName | Initials |
| E | Tarkowski | E |
| M | Tullberg | M |
| P | Fredman | P |
| C | Wikkelsö | C |
Affiliation: Department of Rheumatology and Neurology, University of Göteborg, Guldhedsgatan 10, S-413 46, Göteborg, Sweden. elisabeth.tarkowski@immuno.gu.se
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MESH categories and related page links
This article was linked to the MESH categories shown on the left below. The links on the right are related Memletics pages.
Category links from this article:- Adult
- Aged
- Aged, 80 and over
- Brain - pathology, physiopathology
- Brain Mapping
- Case-Control Studies
- Cerebrospinal Fluid Shunts
- Enzyme-Linked Immunosorbent Assay - methods
- Female
- Gait
- Humans
- Hydrocephalus, Normal Pressure - cerebrospinal fluid, metabolism, surgery
- Magnetic Resonance Imaging - instrumentation, methods
- Male
- Mental Status Schedule
- Middle Aged
- Psychometrics - methods
- Psychomotor Performance
- Sulfoglycosphingolipids - cerebrospinal fluid
- Tumor Necrosis Factor-alpha - cerebrospinal fluid, metabolism
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