 |
| Research article summary (published 27 Feb 2003): |
Non-steroidal anti-inflammatory drug (NSAID) use and Alzheimer disease in community-dwelling elderly patients.
Full Abstract
OBJECTIVE:
Recently, greater attention has been paid to the role of inflammatory processes in the pathophysiology of Alzheimer disease (AD). However, the mechanism by which anti-inflammatory agents (NSAIDs) might slow the progression of AD is not completely known. The aim of the present study was to examine the relationship between NSAIDs use and AD in a large sample of community-dwelling elderly people.
METHODS:
In a cross-sectional retrospective study, the authors analyzed data on patients admitted to home care programs. A total of 12 home health agencies participated in the project, with a total of 2,708 patients enrolled in the present study. The main outcome measures were the prevalence of AD and use of NSAIDs treatment.
RESULTS:
Compared with all non-users, NSAID users had a nearly 50% lower risk of being affected by AD. Separate multivariate analyses of subjects receiving different types of NSAIDs found a significantly decreased risk of cognitive impairment associated with non-aspirin NSAID use, whereas, among subjects taking aspirin, the difference in estimated risk did not reach statistical significance.
CONCLUSION:
The results of this population-based cross-sectional study are consistent with the notion that long-term NSAIDs use has a protective effect against AD. However, after possible confounding effects of age and several other variables potentially associated with cognitive impairment were controlled, this association was statistically significant only for non-aspirin NSAIDs use.
Learn Faster Today Improve your study skills
Author information
Author/s: Landi, Francesco (F); Cesari, Matteo (M); Onder, Graziano (G); Russo, Andrea (A); Torre, Sergio (S); Bernabei, Roberto (R);
Affiliation: Department of Gerontology-Geriatric and Physiatric, Catholic University of the Sacred Heart, Rome, Italy. francesco_landi(-atsign-)rm.unicatt.it.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry (Am J Geriatr Psychiatry), published in United States. (Language: eng)
Reference: -2003 Mar-Apr; vol 11 (issue 2) : pp 179-85
Dates: Created 2003/03/03; Completed 2003/07/03; Revised 2006/11/15;
PMID: 12611747, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.