Neurotransmission of cognition, part 2. Selective NRIs are smart drugs: exploiting regionally selective actions on both dopamine and norepinephrine to enhance cognition.

Full Abstract

ISSUE:
Selective norepinephrine reuptake inhibitors such as atomoxetine increase both dopamine and norepinephrine in frontal cortex and may thereby enhance cognitive functioning in attention-deficit/hyperactivity disorder.

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Author information

Author/s: Stahl, Stephen M (SM);

Affiliation: Neuroscience Education Institute, Carlsbad, Calif 92009, USA.

Journal and publication information

Publication Type: Journal Article

Journal: The Journal of clinical psychiatry (J Clin Psychiatry), published in United States. (Language: eng)

Reference: 2003-Feb; vol 64 (issue 2) : pp 110-1

Dates: Created 2003/03/13; Completed 2003/03/26; Revised 2005/11/17;

PMID: 12633117, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adrenergic Uptake Inhibitors - pharmacology
Antidepressive Agents - pharmacology
Attention Deficit Disorder with Hyperactivity - drug therapy
Cognition - drug effects; physiology
Dopamine - physiology
Dopamine Plasma Membrane Transport Proteins
Frontal Lobe - drug effects; physiology
Humans

Membrane Glycoproteins
Membrane Transport Proteins - physiology
Nerve Tissue Proteins
Norepinephrine - antagonists & inhibitors; physiology
Norepinephrine Plasma Membrane Transport Proteins
Propylamines - pharmacology
Symporters - physiology
Synaptic Transmission - physiology

Associated Chemicals: Adrenergic Uptake Inhibitors (0) ; Antidepressive Agents (0) ; Dopamine Plasma Membrane Transport Proteins (0) ; Membrane Glycoproteins (0) ; Membrane Transport Proteins (0) ; Nerve Tissue Proteins (0) ; Norepinephrine Plasma Membrane Transport Proteins (0) ; Propylamines (0) ; SLC6A2 protein, human (0) ; Symporters (0) ; Norepinephrine (51-41-2) ; Dopamine (51-61-6) ; atomoxetine (83015-26-3)

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