Neurotransmission of cognition, part 3. Mechanism of action of selective NRIs: both dopamine and norepinephrine increase in prefrontal cortex.

Full Abstract

ISSUE:
Selective norepinephrine reuptake inhibitors exploit the fact that dopamine transporters are absent in prefrontal cortex, so dopamine has to hitchhike a ride on the norepinephrine transporter in order to be inactivated. Thus, blocking norepinephrine transporters leads to an increase in both dopamine and norepinephrine levels in prefrontal cortex as well as improvement in cognition in attention-deficit/hyperactivity disorder.

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Author information

Author/s: Stahl, Stephen M (SM);

Affiliation: Neuroscience Education Institute, Carlsbad, CA 92009, USA.

Journal and publication information

Publication Type: Journal Article

Journal: The Journal of clinical psychiatry (J Clin Psychiatry), published in United States. (Language: eng)

Reference: 2003-Mar; vol 64 (issue 3) : pp 230-1

Dates: Created 2003/04/28; Completed 2003/05/09; Revised 2005/11/17;

PMID: 12716261, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adrenergic Uptake Inhibitors - pharmacology; therapeutic use
Attention Deficit Disorder with Hyperactivity - drug therapy; psychology
Cognition - drug effects
Dopamine - metabolism
Dopamine Plasma Membrane Transport Proteins
Humans
Membrane Glycoproteins

Membrane Transport Proteins - drug effects; metabolism
Nerve Tissue Proteins
Norepinephrine - metabolism
Norepinephrine Plasma Membrane Transport Proteins
Prefrontal Cortex - chemistry; drug effects; metabolism
Symporters - antagonists & inhibitors; metabolism
Synaptic Transmission - drug effects

Associated Chemicals: Adrenergic Uptake Inhibitors (0) ; Dopamine Plasma Membrane Transport Proteins (0) ; Membrane Glycoproteins (0) ; Membrane Transport Proteins (0) ; Nerve Tissue Proteins (0) ; Norepinephrine Plasma Membrane Transport Proteins (0) ; SLC6A2 protein, human (0) ; Symporters (0) ; Norepinephrine (51-41-2) ; Dopamine (51-61-6)

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