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| Research article summary (published 27 Feb 2003): |
The neuropsychology of depression: a literature review and preliminary model.
Full Abstract
Neuropsychological research provides a useful framework to study emotional problems, such as depression, and their correlates. This paper reviews several prominent neuropsychological theories. Functional neuroanatomical systems of emotion and depression are reviewed, including those that describe cerebral asymmetries in emotional processing. Following the review, a model that is composed of three neuroanatomical divisions (left frontal, right frontal, and right posterior) and corresponding neuropsychological emotional sequelae within each quadrant is presented. It is proposed that dysfunction in any of these quadrants could lead to symptomatology consistent with a diagnosis of depression. The proposed model combines theories of arousal, lateralization, and functional cerebral space and lends itself to scientific methods of investigation. Accordingly, research, prevention, and treatment programs in accordance with the proposed model may promote an improved understanding of the neuropsychological mechanisms involved in depression.
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Author information
Author/s: Shenal, Brian V (BV); Harrison, David W (DW); Demaree, Heath A (HA);
Affiliation: Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Journal and publication information
Publication Type: Journal Article; Review
Journal: Neuropsychology review (Neuropsychol Rev), published in United States. (Language: eng)
Reference: 2003-Mar; vol 13 (issue 1) : pp 33-42
Dates: Created 2003/04/14; Completed 2003/05/14; Revised 2006/11/15;
PMID: 12691500, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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