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| Research article summary (published 30 May 2002): |
Neuropsychological functioning in elderly patients with schizophrenia and Alzheimer's disease.
Full Abstract
Cognitive functioning was compared in elderly patients with schizophrenia, elderly patients with probable Alzheimer's disease (AD), and matched healthy controls using a brief neuropsychological battery. Both schizophrenia and AD patients demonstrated marked impairment as compared to controls, with the profile of neuropsychological deficits in both disorders appearing remarkably similar. Only visual confrontation naming, verbal delayed recall, and rate of forgetting (i.e. savings score) significantly differentiated between the two patient groups, with AD patients showing poorer overall recall and more rapid forgetting of verbal information over delay. In addition, schizophrenia subjects showed a significantly greater deficit in visual confrontation naming than the AD group. The relationship of neuropsychological function and clinical symptoms of schizophrenia subjects was also examined. Results showed that word list learning, delayed recall, and rate of forgetting correlated most strongly with positive and negative symptoms. Recent neuropathological studies have indicated abnormalities in specific subfields of the hippocampal formation in schizophrenia that are also severely affected in AD. Though the specific histopathology of the two disorders differs, abnormalities in the common sites may underlie the common neuropsychological profile.
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Author information
Author/s: McBride, Thomas (T); Moberg, Paul J (PJ); Arnold, Steven E (SE); Mozley, Lyn Harper (LH); Mahr, Richard N (RN); Gibney, Maureen (M); Kumar, Anand (A); Gur, Raquel E (RE);
Affiliation: Brain Behaviour Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia 19104, USA. mcbride(-atsign-)bblmail.psycha.upenn.edu
Grants: AG 10124 (Agency:United States NIA) ; MH19112 (Agency:United States NIMH) ; MH43880 (Agency:United States NIMH)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.
Journal: Schizophrenia research (Schizophr Res), published in Netherlands. (Language: eng)
Reference: 2002-Jun; vol 55 (issue 3) : pp 217-27
Dates: Created 2002/06/05; Completed 2002/07/30; Revised 2007/11/14;
PMID: 12048145, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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