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| Research article summary (published 30 Jul 2003): |
Neuropsychological effects of ethylene dichloride exposure.
Full Abstract
Production of 1,2-dichloroethane (EDC) has increased and exposure to it has been reported to produce adverse effects in animals and CNS effects in humans. A group of 221 EDC exposed hazardous clean-up workers incurred chronic exposure to EDC without protective equipment. A clinical history and the following tests were administered:
the WHO Adult Environmental Neurobehavioral Test Battery (AENTB), Wechsler Adult Intelligence Scale (WAIS-III), Wechsler Memory Scale (WMS-III); WRAT 3 Reading, Cancellation H, Trail Making, Stroop, Rey Osterreith, Animal Naming, COWAT, TOMM, Rey 15, Lanthony d-15 Color Vision, and Vistech Contrast Sensitivity. Mood and symptoms were assessed with the SCL90-R, BDI, BAI and IES. The clinical neuropsychological evaluation of these workers indicates lower neuropsychological functioning in the domains of processing speed; attention; cognitive flexibility; motor coordination and speed; verbal memory; verbal fluency; and visuo-spatial abilities. These workers also showed disturbed mood and impaired vision. Dose/response relationships between exposure to EDC and test scores are shown.
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Author information
Author/s: Bowler, Rosemarie M (RM); Gysens, Sabine (S); Hartney, Christopher (C);
Affiliation: rbowl(-atsign-)sfsu.edu
Journal and publication information
Publication Type: Comparative Study; Journal Article
Journal: Neurotoxicology (Neurotoxicology), published in Netherlands. (Language: eng)
Reference: 2003-Aug; vol 24 (issue 4-5) : pp 553-62
Dates: Created 2003/08/05; Completed 2003/10/27; Revised 2006/11/15;
PMID: 12900069, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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