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| Research article summary (published 29 Apr 2002): |
Neurophysiological and clinical aspects of glucocorticoids and memory: a review.
Full Abstract
Neuropsychologists are increasingly involved in the assessment and treatment of individuals with glucocorticoid (GC) dysfunction. This review examines the clinical and neurophysiological changes associated with alterations in GC levels, with specific emphasis on changes in hippocampal plasticity and memory impairments. Hypothalamic-pituitary-adrenal (HPA) axis regulation of GC production and GC effects at hippocampal receptors are examined. GC-related changes in memory and hippocampal plasticity are considered in a wide array of populations, including animals, healthy adults, patients receiving exogenous GC treatments, and patients with neuropsychiatric disorders resulting in GC dysregulation. Hypotheses regarding GC-related memory changes are considered, with emphasis on hippocampal neurotoxicity and changes in excitatory amino acids, glucose metabolism and neurotrophic factors. These hypotheses are examined, with special attention given to inconsistencies and contradictions within this body of research. Finally, implications for neuropsychological evaluation and future research are presented.
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Author information
Author/s: Alderson, Amy L (AL); Novack, Thomas A (TA);
Affiliation: Department of Physical Medicine & Rehabilitation, University of Alabama at Birmingham, USA. amy_alderson(-atsign-)shepherd.org
Grants: HD07420 (Agency:United States NICHD)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review
Journal: Journal of clinical and experimental neuropsychology (J Clin Exp Neuropsychol), published in Netherlands. (Language: eng)
Reference: 2002-May; vol 24 (issue 3) : pp 335-55
Dates: Created 2002/05/06; Completed 2002/06/20; Revised 2008/04/14;
PMID: 11992216, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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