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| Research article summary (published 5 May 2002): |
Neuronal tissue polarization induced by repetitive transcranial magnetic stimulation?
Full Abstract
In a blinded cross-over design, 10 healthy controls received 900 monophasic and biphasic repetitive transcranial magnetic stimuli over the primary motor cortex. Stimulation frequency was 1 Hz, and stimulation intensity 90% of the individual resting motor threshold. Suprathreshold stimuli applied at 0.1 Hz before and after repetitive stimulation controlled for changes in corticospinal excitability. We found a lasting corticospinal inhibition that was significantly more pronounced after monophasic than after biphasic repetitive transcranial magnetic stimulation (motor evoked potential amplitude reduced by 35 +/- 20% vs 12 +/- 37%, mean+/- s.d.). We propose that the current flow in the coil plays a significant role in optimising after effects, and asymmetric current flow may be particularly efficient in building up tissue polarization.
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Author information
Author/s: Sommer, Martin (M); Lang, Nicolas (N); Tergau, Frithjof (F); Paulus, Walter (W);
Affiliation: Department of Clinical Neurophysiology, University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Neuroreport (Neuroreport), published in England. (Language: eng)
Reference: 2002-May; vol 13 (issue 6) : pp 809-11
Dates: Created 2002/05/08; Completed 2002/06/26; Revised 2006/11/15;
PMID: 11997692, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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