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| Research article summary (published 13 Nov 2002): |
Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies.
Full Abstract
An approach was used to identify the oxidized nucleoside, 8-hydroxyguanosine in brains of dementia with Lewy bodies. Neurons with marked immunoreaction of 8-hydroxyguanosine in the cytoplasm were widely distributed in the hippocampal region and temporal neocortex. Relative intensity measurements of neuronal 8-hydroxyguanosine immunoreactivity showed that there was a significant increase in nucleic acid oxidation in dementia with Lewy bodies compared with controls. Treatment with nuclease (DNase or RNase) before the immunostaining demonstrated that RNA was a major site of nucleic acid oxidation. Together with the previously reported RNA oxidation in vulnerable neurons in Alzheimer and Parkinson diseases, neuronal RNA oxidation in dementia with Lewy bodies might represent one of the fundamental abnormalities in age-associated neurodegenerative diseases.
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Author information
Author/s: Nunomura, Akihiko (A); Chiba, Shigeru (S); Kosaka, Kenji (K); Takeda, Atsushi (A); Castellani, Rudy J (RJ); Smith, Mark A (MA); Perry, George (G);
Affiliation: Department of Psychiatry and Neurology, Asahikawa Medical College, Higashi 2-1-1-1, Midorigaoka, Asahikawa 078-8510, Japan. nuno(-atsign-)asahika-med.ac.jp
Grants: NS38648 (Agency:United States NINDS)
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Neuroreport (Neuroreport), published in England. (Language: eng)
Reference: 2002-Nov; vol 13 (issue 16) : pp 2035-9
Dates: Created 2002/11/19; Completed 2003/04/17; Revised 2007/11/14;
PMID: 12438921, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
Comments and Corrections
ErratumIn: Neuroreport. 2003 Feb 10;14(2):293..
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