 |
| Research article summary (published 30 Oct 2002): |
Neuronal and glial metabolite content of the epileptogenic human hippocampus.
Full Abstract
Mesial temporal lobe epilepsy is characterized by hippocampal atrophy, hypometabolism, and decreased N-acetylaspartate, often attributed to neuron loss and gliosis. Twenty hippocampal specimens were obtained during temporal lobectomy and frozen quickly. Perchloric acid extracts of the small metabolites were analyzed by proton magnetic resonance spectroscopy. There were no significant associations between hippocampal neuron loss and the cellular content of N-acetylaspartate, glutamate, GABA, glutamine, or aspartate. The mean metabolite content of hippocampi with less than 30% of neurons remaining was the same as those with greater than 65% of neurons surviving. Mean N-acetylaspartate levels were below those reported by in vivo studies of control subjects. The highest and the lowest glutamate concentrations were seen in specimens with the worst neuron loss. A highly significant association between hippocampal N-acetylaspartate and glutamate content was seen with weak associations between N-acetylaspartate and aspartate and glutamate and aspartate. The hippocampal content of N-acetylaspartate, glutamate, GABA, glutamine, and aspartate is altered minimally by severe neuron loss in mesial temporal lobe epilepsy. The epileptic human hippocampus has increased intracellular glutamate content that may contribute to the epileptogenic nature of hippocampal sclerosis.
Learn Faster Today Improve your study skills
Author information
Author/s: Petroff, Ognen A C (OA); Errante, Laura D (LD); Rothman, Douglas L (DL); Kim, Jung H (JH); Spencer, Dennis D (DD);
Affiliation: Department of Neurology, Yale University, 333 Cedar Street, New Haven, CT 06520-8018, USA. ognen.petroff(-atsign-)yale.edu
Grants: P01 NS 39092 (Agency:United States NINDS)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: Annals of neurology (Ann Neurol), published in United States. (Language: eng)
Reference: 2002-Nov; vol 52 (issue 5) : pp 635-42
Dates: Created 2002/10/28; Completed 2002/12/03; Revised 2007/11/14;
PMID: 12402262, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.