 |
| Research article summary (published Feb 2003): |
Neuron-specific age-related decreases in dopamine receptor subtype mRNAs.
Full Abstract
Age-related decline in dopamine receptor levels has been observed in regional studies of animal and human brains; however, identifying specific cellular substrates and/or alterations in distinct neuronal populations remains elusive. To evaluate whether age-related decreases in dopamine receptor subtypes are associated with specific cell populations in the hippocampus and entorhinal cortex, antisense RNA amplification was combined with cDNA array analysis to examine effects of aging on D1-D5 dopamine receptor mRNA expression levels in hippocampal CA1 pyramidal neurons and entorhinal cortex layer II stellate cells from post-mortem human brains (19-92 years). In CA1 pyramidal neurons, significant age-related decline was observed for dopamine receptor mRNAs (D1-D4, P < 0.001; D5, P < 0.05) but not for the cytoskeletal elements beta-actin, three-repeat (3R) tau, and four-repeat (4R) tau. In contrast, no significant changes were observed in stellate cells across the same cohort. Thus, senescence may be a factor responsible for cell-specific decrements in dopamine receptor gene expression in one population of neurons within a circuit that is critical for learning and memory. Furthermore, these results support the hypothesis that alterations in dopaminergic function may also be related to behavioral abnormalities, such as psychosis, that occur with aging.Copyright 2002 Wiley-Liss, Inc.
Learn Faster Today Improve your study skills
Author information
Author/s: Hemby, Scott E (SE); Trojanowski, John Q (JQ); Ginsberg, Stephen D (SD);
Affiliation: Department of Pharmacology and Psychiatry/Behavioral Sciences, Yerkes National Primate Research Center, Neuroscience Division, Emory University School of Medicine, Atlanta, Georgia 30329, USA. shemby(-atsign-)pharm.emory.edu
Grants: AG09215 (Agency:United States NIA) ; AG10124 (Agency:United States NIA) ; AG10668 (Agency:United States NIA) ; DA013772 (Agency:United States NIDA) ; NS043939 (Agency:United States NINDS) ; R01 DA013772-03 (Agency:United States NIDA)
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: The Journal of comparative neurology (J Comp Neurol), published in United States. (Language: eng)
Reference: 2003-Feb; vol 456 (issue 2) : pp 176-83
Dates: Created 2003/01/01; Completed 2003/03/17; Revised 2007/11/14;
PMID: 12509874, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.