 |
| Research article summary (published 10 Dec 2001): |
Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation.
Full Abstract
Neurofibrillary tangle (NFT) formation in the CA1 region of the hippocampus is one of the early events in the pathogenesis of Alzheimer's disease (AD). As the disease progresses more NFTs form and there is substantial neuron loss. In this study we investigated whether NFT formation accounts for all the CA1 pyramidal neuron loss seen in AD. Using unbiased stereological techniques, we estimated the total number of neurons and the number of intra- and extra-cellular NFTs in the hippocampus of 10 patients with AD and 10 age-matched controls. Marked neuronal loss (approximately 60%) was identified in AD, although NFTs accounted for only a small proportion of this loss (2.2-17.2%, mean 8.1%). Analysis of NFT accumulation with duration of dementia showed a linear relationship, supporting the belief that NFTs progressively accumulate with time.
Learn Faster Today Improve your study skills
Author information
Author/s: Kril, Jillian J (JJ); Patel, Smita (S); Harding, Antony J (AJ); Halliday, Glenda M (GM);
Affiliation: Department of Pathology, The University of Sydney, Sydney, Australia. jilliank(-atsign-)med.usyd.edu.au
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Acta neuropathologica (Acta Neuropathol), published in Germany. (Language: eng)
Reference: 2002-Apr; vol 103 (issue 4) : pp 370-6
Dates: Created 2002/03/20; Completed 2002/05/07; Revised 2007/11/09;
PMID: 11904757, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.