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| Research article summary (published 30 May 2002): |
Neuromodulation, theta rhythm and rat spatial navigation.
Full Abstract
Cholinergic and GABAergic innervation of the hippocampus plays an important role in human memory function and rat spatial navigation. Drugs which block acetylcholine receptors or enhance GABA receptor activation cause striking impairments in the encoding of new information. Lesions of the cholinergic innervation of the hippocampus reduce the amplitude of hippocampal theta rhythm and cause impairments in spatial navigation tasks, including the Morris water maze, eight-arm radial maze, spatial reversal and delayed alternation. Here, we review previous work on the role of cholinergic modulation in memory function, and we present a new model of the hippocampus and entorhinal cortex describing the interaction of these regions for goal-directed spatial navigation in behavioral tasks. These mechanisms require separate functional phases for:
(1) encoding of pathways without interference from retrieval, and (2) retrieval of pathways for guiding selection of the next movement. We present analysis exploring how phasic changes in physiological variables during hippocampal theta rhythm could provide these different phases and enhance spatial navigation function.
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Author information
Author/s: Hasselmo, Michael E (ME); Hay, Jonathan (J); Ilyn, Maxim (M); Gorchetchnikov, Anatoli (A);
Affiliation: Department of Psychology, Center for BioDynamics, Boston University, MA 02215, USA. hasselmo(-atsign-)bu.edu
Grants: MH60013 (Agency:United States NIMH) ; MH60450 (Agency:United States NIMH) ; MH61492 (Agency:United States NIMH)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
Journal: Neural networks : the official journal of the International Neural Network Society (Neural Netw), published in United States. (Language: eng)
Reference: -2002 Jun-Jul; vol 15 (issue 4-6) : pp 689-707
Dates: Created 2002/10/09; Completed 2003/02/11; Revised 2007/11/14;
PMID: 12371520, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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