Neuromagnetic evidence for a pitch processing center in Heschl's gyrus.

Full Abstract

There have been several attempts to use the neuromagnetic response to the onset of a tonal sound (N100m) to study pitch processing in auditory cortex. Unfortunately, a large proportion of the N100m is simply a response to the onset of sound energy, independent of whether the sound produces a pitch. The current study describes a novel stimulus paradigm designed to circumvent the energy-onset response and thereby isolate the response of those neural elements specifically involved in pitch processing. The temporal resolution of magnetoencephalography enables us to show that the latency and amplitude of this pitch-onset response (POR) vary with the pitch and pitch strength of the tone. The spatial resolution is sufficient to show that its source lies somewhat anterior and inferior to that of the N100m, probably in the medial part of Heschl's gyrus.

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Author information

Author/s: Krumbholz, K (K); Patterson, R D (RD); Seither-Preisler, A (A); Lammertmann, C (C); Lütkenhöner, B (B);

Affiliation: Institute of Experimental Audiology, University Clinic Münster, Münster, Germany. k.krumbholtz(-atsign-)fz-juelich.de

Journal and publication information

Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

Journal: Cerebral cortex (New York, N.Y. : 1991) (Cereb Cortex), published in United States. (Language: eng)

Reference: 2003-Jul; vol 13 (issue 7) : pp 765-72

Dates: Created 2003/06/20; Completed 2003/08/15; Revised 2006/11/15;

PMID: 12816892, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acoustic Stimulation - methods
Auditory Cortex - physiology
Brain Mapping - methods
Evoked Potentials, Auditory - physiology
Humans

Magnetoencephalography - methods
Noise
Pitch Discrimination - physiology
Pitch Perception - physiology
Reaction Time - physiology

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