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| Research article summary (published 30 Aug 2002): |
Neurological soft signs in first-episode psychosis: a systematic review.
Full Abstract
BACKGROUND:
Neurological soft signs (NSS) are minor neurological signs indicating non-specific cerebral dysfunction. Their presence has been documented extensively in schizophrenia but not during the first psychotic episode.
AIMS:
To review studies that have specifically investigated NSS at the time of the first psychotic episode.
METHOD:
A review of studies investigating neurological function in first-episode psychosis, using a clinical examination.
RESULTS:
Patients with first-episode psychosis show an excess of NSS, particularly in the areas of motor coordination and sequencing, sensory integration and in developmental reflexes. Furthermore, NSS may be associated with a specific laterality pattern.
CONCLUSIONS:
More studies on first-onset schizophrenia are needed, evaluating both sensory and motor neurological domains (scoring separately for the two sides of the body), integrating this knowledge with neuroimaging findings and clarifying the role of NSS as markers of cognitive dysfunction.
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Author information
Author/s: Dazzan, Paola (P); Murray, Robin M (RM);
Affiliation: Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF. spcbpad(-atsign-)iop.kcl.ac.uk
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
Journal: The British journal of psychiatry. Supplement (Br J Psychiatry Suppl), published in England. (Language: eng)
Reference: 2002-Sep; vol 43 (issue ) : pp s50-7
Dates: Created 2002/09/25; Completed 2002/11/22; Revised 2008/02/22;
PMID: 12271801, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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