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| Research article summary (published 30 Jan 2002): |
Neuroimaging a single thought: dorsolateral PFC activity associated with refreshing just-activated information.
Full Abstract
Neuroimaging studies of human working memory (WM) show conflicting results regarding whether dorsolateral prefrontal cortex (PFC) contributes to maintaining information in consciousness or is recruited primarily when information must be manipulated. Using functional magnetic resonance imaging (fMRI), we looked at a minimal maintenance process--thinking back to a single, just-seen stimulus (refreshing). We found greater activity in left dorsolateral PFC (BA9) when participants refreshed a word compared to reading a word once or a second time. Furthermore, recognition memory was subsequently more accurate and faster for items that had been refreshed, demonstrating that a single thought that maintains activation can have consequences for long-term memory. Our fMRI results call into question any class of models of the functional organization of PFC and WM that associates simple and/or maintenance processes only with ventrolateral PFC or that associates dorsolateral PFC only with more complex processes such as manipulation.
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Author information
Author/s: Raye, Carol L (CL); Johnson, Marcia K (MK); Mitchell, Karen J (KJ); Reeder, John A (JA); Greene, Erich J (EJ);
Affiliation: Yale University, New Haven, Connecticut 06520, USA.
Grants: AG09253 (Agency:United States NIA) ; AG15793 (Agency:United States NIA)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
Journal: NeuroImage (Neuroimage), published in United States. (Language: eng)
Reference: 2002-Feb; vol 15 (issue 2) : pp 447-53
Dates: Created 2002/01/18; Completed 2002/04/19; Revised 2007/11/14;
PMID: 11798278, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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