Research article summary (published 27 Feb 2003):

The neurochemical hypothesis of 'theory of mind'.

Full Abstract

This paper aims to explore the neurochemical basis of the ability to represent one's own or other's mental states such as intentions, beliefs, wants and knowledge, an ability often referred to as 'theory of mind'. Based on neurochemical and psychopharmacological investigations in autism and schizophrenia, pathologies in which this ability is impaired, it is hypothesized that 'theory of mind' abilities are contingent on the integrity of the serotonergic and dopaminergic system. This hypothesis is discussed in light of the system's neurochemical properties and role in cognition. It is suggested that specific abnormalities to this system can account for differences in the profile of 'theory of mind' impairments that may exist among patients belonging to different pathologies.

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Author information

Author/s: Abu-Akel, A (A);

Affiliation: PLD Research Center, Arara, Israel. abuakel(-atsign-)hotmail.com

Journal and publication information

Publication Type: Journal Article

Journal: Medical hypotheses (Med Hypotheses), published in Scotland. (Language: eng)

Reference: 2003-Mar; vol 60 (issue 3) : pp 382-6

Dates: Created 2003/02/12; Completed 2003/10/01; Revised 2004/11/17;

PMID: 12581615, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Autistic Disorder - physiopathology Brain - anatomy & histology; physiology Cognition Cognition Disorders Dopamine - metabolism Humans

Mental Processes Models, Theoretical Neurochemistry - methods Schizophrenia - physiopathology Serotonin - metabolism Social Perception

Associated Chemicals: Serotonin (50-67-9) ; Dopamine (51-61-6)

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