Neurobehavioral effects of vanadium.

Full Abstract

It was our aim to study whether chronic exposure to vanadium reduces cognitive abilities. We investigated effects on attention, visuospatial and visuomotor functioning, reaction time, short-term memory, and prefrontal functioning. Forty-nine vanadium exposed subjects with a mean vanadium level in urine (VanU) of 14.4 micro/L and 49 controls (VanU:
0.8 microg/L) with the same socioeconomic background were investigated. Neuropsychological tests were done using a modified Wisconsin Card Sorting Test (WCST), Block Design Test (BDT), Visual Recognition Test (VRT), Simple Reaction Time (SRT), Choice Reaction (CR), Digit Symbol Substitution (DSS), and Digit Span (DS). Exposure was assessed by using the vanadium level in urine and serum. While there were significant differences in BDT and DSS, no differences were found in WCST, SRT, CR, and DS. Significant correlations existed between the vanadium levels in urine and serum and the cognitive deficits. Vanadium concentrations around 14.2 microg/L in urine reduce neurobehavioral abilities, particularly visuospatial abilities and attention.

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Author information

Author/s: Barth, A (A); Schaffer, A W (AW); Konnaris, C (C); Blauensteiner, R (R); Winker, R (R); Osterode, W (W); Rüdiger, H W (HW);

Affiliation: Division of Occupational Medicine, University of Vienna, Austria. alfred.barth(-atsign-)akh-wien.ac.at

Journal and publication information

Publication Type: Clinical Trial; Journal Article

Journal: Journal of toxicology and environmental health. Part A (J Toxicol Environ Health A), published in England. (Language: eng)

Reference: 2002-May; vol 65 (issue 9) : pp 677-83

Dates: Created 2002/05/08; Completed 2002/05/22; Revised 2006/02/16;

PMID: 11996408, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Attention - drug effects
Cognition - drug effects
Dose-Response Relationship, Drug
Humans
Male
Memory, Short-Term - drug effects
Metallurgy
Middle Aged

Middle Aged
Neuropsychological Tests
Occupational Exposure - adverse effects
Prefrontal Cortex - drug effects
Psychomotor Performance - drug effects
Reaction Time - drug effects
Smoking
Space Perception - drug effects
Vanadium - blood; toxicity; urine

Associated Chemicals: Vanadium (7440-62-2)

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