Neural responses during anticipation of a primary taste reward.

Full Abstract

The aim of this study was to determine the brain regions involved in anticipation of a primary taste reward and to compare these regions to those responding to the receipt of a taste reward. Using fMRI, we scanned human subjects who were presented with visual cues that signaled subsequent reinforcement with a pleasant sweet taste (1 M glucose), a moderately unpleasant salt taste (0.2 M saline), or a neutral taste. Expectation of a pleasant taste produced activation in dopaminergic midbrain, posterior dorsal amygdala, striatum, and orbitofrontal cortex (OFC). Apart from OFC, these regions were not activated by reward receipt. The findings indicate that when rewards are predictable, brain regions recruited during expectation are, in part, dissociable from areas responding to reward receipt.

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Author information

Author/s: O'Doherty, John P (JP); Deichmann, Ralf (R); Critchley, Hugo D (HD); Dolan, Raymond J (RJ);

Affiliation: Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, WC1 3BG, London, United Kingdom. j.odoherty(-atsign-)fil.ion.ucl.ac.uk

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuron (Neuron), published in United States. (Language: eng)

Reference: 2002-Feb; vol 33 (issue 5) : pp 815-26

Dates: Created 2002/03/06; Completed 2002/03/29; Revised 2006/11/15;

PMID: 11879657, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Neuron. 2002 Feb 28;33(5):668-71. (PMID: 11879644)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Animals
Brain - physiology
Brain Mapping
Cues
Emotions - physiology
Female

Glucose
Humans
Magnetic Resonance Imaging
Male
Reinforcement (Psychology)
Reward
Salts
Taste - physiology

Associated Chemicals: Salts (0) ; Glucose (50-99-7)

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