The neural network basis for abnormalities of attention and executive function in major depressive disorder: implications for application of the medical disease model to psychiatric disorders.

Full Abstract

The deficits in attention and executive function characteristic of major depressive disorder (MDD) are reviewed. The networks underlying attention and executive function, the neuropsychological tests commonly used to evaluate these domains, and the neuroanatomy of MDD are also discussed. A neural network approach to the attentional and executive function deficits of MDD has ramifications for hypothesis-guided research, the cognitive model of depression, and application of the medical disease model to psychiatric disorders.

Learn Faster Today Improve your study skills

Author information

Author/s: Ottowitz, William E (WE); Dougherty, Darin D (DD); Savage, Cary R (CR);

Affiliation: Psychiatric Neuroscience Program, Massachusetts General Hospital, Charlestown, Mass 02129, USA. ottowitz(-atsign-)psych.mgh.harvard.edu

Journal and publication information

Publication Type: Journal Article; Review

Journal: Harvard review of psychiatry (Harv Rev Psychiatry), published in United States. (Language: eng)

Reference: -2002 Mar-Apr; vol 10 (issue 2) : pp 86-99

Dates: Created 2002/03/18; Completed 2002/05/14; Revised 2005/11/16;

PMID: 11897749, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Attention - physiology
Cerebral Cortex - physiopathology
Depressive Disorder, Major - diagnosis; physiopathology; psychology
Diagnostic Imaging

Humans
Nerve Net - physiopathology
Neuropsychological Tests
Problem Solving - physiology

These are the highest related articles currently in the database:

See 100+ related articles.