Neural correlates of successful and unsuccessful verbal memory encoding.

Full Abstract

Recent neuroimaging studies suggest that episodic memory encoding involves a network of neocortical structures which may act interdependently with medial temporal lobe (mTL) structures to promote the formation of durable memories, and that activation in certain structures is modulated according to task performance. Functional magnetic resonance imaging (fMRI) was used to determine the neural structures recruited during a verbal episodic encoding task and to examine the relationship between activation during encoding and subsequent recognition memory performance across subjects. Our results show performance-correlated activation during encoding both in neocortical and medial temporal structures. Neocortical activations associated with later successful and unsuccessful recognition memory were found to differ not only in magnitude, but also in hemispheric laterality. These performance-related hemispheric effects, which have not been previously reported, may correspond to between-subject differences in encoding strategy.Copyright 2002 Elsevier Science (USA).

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Author information

Author/s: Casasanto, Daniel J (DJ); Killgore, William D S (WD); Maldjian, Joseph A (JA); Glosser, Guila (G); Alsop, David C (DC); Cooke, Ayanna M (AM); Grossman, Murray (M); Detre, John A (JA);

Affiliation: Department of Neurology, University of Pennsylvania Medical Center and Brain Imaging Center, Philadelphia 19104, USA.

Grants: NS02079 (Agency:NINDS NIH HHS) ; NS37488 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal: Brain and language (Brain Lang), published in United States. (Language: eng)

Reference: 2002-Mar; vol 80 (issue 3) : pp 287-95

Dates: Created 2002/03/18; Completed 2002/05/21; Revised 2007/11/14;

PMID: 11896642, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Cognition - physiology
Female
Functional Laterality - physiology
Humans

Humans
Magnetic Resonance Imaging
Male
Memory - physiology
Temporal Lobe - anatomy & histology; physiology
Vocabulary

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