Neural correlates for feeling-of-knowing: an fMRI parametric analysis.

Full Abstract

The "feeling-of-knowing" (FOK) is a subjective sense of knowing a word before recalling it, and the FOK provides us clues to understanding the mechanisms of human metamemory systems. We investigated neural correlates for the FOK based on the recall-judgment-recognition paradigm. Event-related functional magnetic resonance imaging with a parametric analysis was used. We found activations in left dorsolateral, left anterior, bilateral inferior, and medial prefrontal cortices that significantly increased as the FOK became greater, and the activations remained significant even when the potentially confounding factor of the response latency was removed. Furthermore, we demonstrated that the FOK region in the right inferior frontal gyrus and a subset of the FOK region in the left inferior frontal gyrus are not recruited for successful recall processes, suggesting their particular role in metamemory processing.

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Author information

Author/s: Kikyo, Hideyuki (H); Ohki, Kenichi (K); Miyashita, Yasushi (Y);

Affiliation: Department of Physiology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuron (Neuron), published in United States. (Language: eng)

Reference: 2002-Sep; vol 36 (issue 1) : pp 177-86

Dates: Created 2002/10/07; Completed 2002/11/04; Revised 2006/11/15;

PMID: 12367516, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Brain - anatomy & histology; physiology
Brain Mapping
Cognition - physiology
Female
Functional Laterality - physiology
Humans
Magnetic Resonance Imaging

Magnetic Resonance Imaging
Male
Memory - physiology
Nerve Net - anatomy & histology; physiology
Neural Pathways - anatomy & histology; physiology
Neuropsychological Tests
Reaction Time - physiology
Verbal Behavior - physiology

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