Neural correlates of the automatic processing of threat facial signals.

Full Abstract

The present study examined whether automaticity, defined here as independence from attentional modulation, is a fundamental principle of the neural systems specialized for processing social signals of environmental threat. Attention was focused on either scenes or faces presented in a single overlapping display. Facial expressions were neutral, fearful, or disgusted. Amygdala responses to facial expressions of fear, a signifier of potential physical attack, were not reduced with reduced attention to faces. In contrast, anterior insular responses to facial expressions of disgust, a signifier of potential physical contamination, were reduced with reduced attention. However, reduced attention enhanced the amygdala response to disgust expressions; this enhanced amygdala response to disgust correlated with the magnitude of attentional reduction in the anterior insular response to disgust. These results suggest that automaticity is not fundamental to the processing of all facial signals of threat, but is unique to amygdala processing of fear. Furthermore, amygdala processing of fear was not entirely automatic, coming at the expense of specificity of response. Amygdala processing is thus specific to fear only during attended processing, when cortical processing is undiminished, and more broadly tuned to threat during unattended processing, when cortical processing is diminished.

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Author information

Author/s: Anderson, Adam K (AK); Christoff, Kalina (K); Panitz, David (D); De Rosa, Eve (E); Gabrieli, John D E (JD);

Affiliation: Department of Psychology, Stanford University, Stanford, California 94305, USA. anderson(-atsign-)psych.utoronto.ca

Grants: MH12829-01 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), published in United States. (Language: eng)

Reference: 2003-Jul; vol 23 (issue 13) : pp 5627-33

Dates: Created 2003/07/04; Completed 2003/08/14; Revised 2007/11/14;

PMID: 12843265, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Amygdala - cytology; physiology
Attention - physiology
Behavior - physiology
Brain Mapping
Face
Female

Female
Hostility
Humans
Magnetic Resonance Imaging
Male
Neurons - physiology
Nonverbal Communication - physiology
Photic Stimulation - methods

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