Neural and behavioral substrates of mood and mood regulation.

Full Abstract

A review of behavioral and neurobiological data on mood and mood regulation as they pertain to an understanding of mood disorders is presented. Four approaches are considered:
1) behavioral and cognitive; 2) neurobiological; 3) computational; and 4) developmental. Within each of these four sections, we summarize the current status of the field and present our vision for the future, including particular challenges and opportunities. We conclude with a series of specific recommendations for National Institute of Mental Health priorities. Recommendations are presented for the behavioral domain, the neural domain, the domain of behavioral-neural interaction, for training, and for dissemination. It is in the domain of behavioral-neural interaction, in particular, that new research is required that brings together traditions that have developed relatively independently. Training interdisciplinary clinical scientists who meaningfully draw upon both behavioral and neuroscientific literatures and methods is critically required for the realization of these goals.

Learn Faster Today Improve your study skills

Author information

Author/s: Davidson, Richard J (RJ); Lewis, David A (DA); Alloy, Lauren B (LB); Amaral, David G (DG); Bush, George (G); Cohen, Jonathan D (JD); Drevets, Wayne C (WC); Farah, Martha J (MJ); Kagan, Jerome (J); McClelland, Jay L (JL); Nolen-Hoeksema, Susan (S); Peterson, Bradley S (BS);

Affiliation: Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

Journal and publication information

Publication Type: Journal Article; Review

Journal: Biological psychiatry (Biol Psychiatry), published in United States. (Language: eng)

Reference: 2002-Sep; vol 52 (issue 6) : pp 478-502

Dates: Created 2002/10/03; Completed 2002/12/06; Revised 2005/11/16;

PMID: 12361665, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Affect
Animals
Behavior
Brain - physiopathology
Cognition
Humans

Models, Neurological
Models, Psychological
Mood Disorders - physiopathology; psychology
National Institute of Mental Health (U.S.)
Research - trends
United States

These are the highest related articles currently in the database:

Multiple memory systems: the power of interactions. 30 Oct 2004
Glucocorticoids and brain functions. 30 Aug 2007
Functional neuroimaging studies of depression: the anatomy of melancholia. 30 Dec 1997
Cannabis and psychiatric disorders: it is not only addiction. 30 May 2008
Brain temperature may influence mood: a hypothesis. 20 Oct 2007
Prenatal exposure to sex steroid hormones and behavioral/cognitive outcomes. 29 Sep 2008
Role of receptor coupling to phosphoinositide metabolism in the therapeutic action of lithium. 30 Dec 1986
Neuroimaging in pursuit of neurobiology: strengths, limitations, and the quest for new paradigms in depression and mood. 30 Dec 1999
Neurotrophins as mediators of drug effects on mood, addiction, and neuroprotection. 30 May 2004
A neurotrophic model for stress-related mood disorders. 19 Apr 2006

See 100+ related articles.