The neural basis of intrusions in free recall and cued recall: a PET study in Alzheimer's disease.

Full Abstract

This study was designed to map in Alzheimer's disease patients the correlations between resting-state brain glucose utilization measured by PET and the number of intrusions obtained by means of a specially designed episodic memory test separately in free recall and in cued recall. SPM revealed significant negative correlations between the number of intrusions in free recall and the metabolism of the right superior frontal gyrus. For the intrusions in cued recall, the negative correlations concerned the left rhinal cortex. Our findings suggest that intrusions in free recall reflect perturbations in strategic processes and that intrusions in cued recall are triggered by the cue in a relatively automatic manner. Frontal dysfunction would be responsible for the former and rhinal dysfunction for the latter.

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Author information

Author/s: Desgranges, Béatrice (B); Baron, Jean-Claude (JC); Giffard, Bénédicte (B); Chételat, Gaël (G); Lalevée, Catherine (C); Viader, Fausto (F); de la Sayette, Vincent (V); Eustache, Francis (F);

Affiliation: INSERM E0218, Université de Caen, Centre CYCERON, CHU Côte de Nacre, 14033, Caen Cedex, France.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: NeuroImage (Neuroimage), published in United States. (Language: eng)

Reference: 2002-Nov; vol 17 (issue 3) : pp 1658-64

Dates: Created 2002/11/04; Completed 2003/02/13; Revised 2006/11/15;

PMID: 12414304, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged
Aged, 80 and over
Alzheimer Disease - physiopathology; radionuclide imaging
Attention - physiology
Blood Glucose - metabolism
Cues
Female
Frontal Lobe - physiopathology; radionuclide imaging

Hippocampus - physiopathology; radionuclide imaging
Humans
Male
Mental Recall - physiology
Middle Aged
Nerve Net - physiopathology; radionuclide imaging
Neuropsychological Tests
Tomography, Emission-Computed

Associated Chemicals: Blood Glucose (0)

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