An N-of-1 randomized controlled trial ('N-of-1 trial') of donepezil in the treatment of non-progressive amnestic syndrome.

Full Abstract

INTRODUCTION:
a professional man sustained a residual, persisting, isolated impairment of short-term memory secondary to severe carbon monoxide poisoning. Informal, open trial of the cholinesterase inhibitor donepezil resulted in uncertain benefit.

PROTOCOL:
an N-of-1 randomized, double-blind controlled trial of donepezil against placebo. Placebo-induced headache permitted evaluation of donepezil at only the 5 mg dose.

RESULTS:
there was no improvement in short-term memory.

CONCLUSION:
the trial excluded significant benefit of donepezil 5 mg in this patient, preventing long-term unnecessary prescription. Beneficial effects in other similar patients or at higher dosage cannot be excluded.

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Author information

Author/s: Price, James D (JD); Grimley Evans, John (J);

Affiliation: Division of Clinical Geratology, Nuffield Department of Clinical Medicine, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK. james.price(-atsign-)geratology.oxford.ac.uk

Journal and publication information

Publication Type: Clinical Trial; Journal Article; Randomized Controlled Trial

Journal: Age and ageing (Age Ageing), published in England. (Language: eng)

Reference: 2002-Jul; vol 31 (issue 4) : pp 307-9

Dates: Created 2002/07/30; Completed 2002/10/11; Revised 2004/11/17;

PMID: 12147570, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Cholinesterase Inhibitors - adverse effects; therapeutic use
Dose-Response Relationship, Drug
Double-Blind Method
Humans

Humans
Indans - adverse effects; therapeutic use
Memory, Short-Term
Piperidines - adverse effects; therapeutic use

Associated Chemicals: Cholinesterase Inhibitors (0) ; Indans (0) ; Piperidines (0) ; donepezil (120011-70-3)

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