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| Research article summary (published 30 May 2002): |
Multisensory auditory-visual interactions during early sensory processing in humans: a high-density electrical mapping study.
Full Abstract
Integration of information from multiple senses is fundamental to perception and cognition, but when and where this is accomplished in the brain is not well understood. This study examined the timing and topography of cortical auditory-visual interactions using high-density event-related potentials (ERPs) during a simple reaction-time (RT) task. Visual and auditory stimuli were presented alone and simultaneously. ERPs elicited by the auditory and visual stimuli when presented alone were summed ('sum' ERP) and compared to the ERP elicited when they were presented simultaneously ('simultaneous' ERP). Divergence between the 'simultaneous' and 'sum' ERP indicated auditory-visual (AV) neural response interactions. There was a surprisingly early right parieto-occipital AV interaction, consistent with the finding of an earlier study [J. Cogn. Neurosci. 11 (1999) 473]. The timing of onset of this effect (46 ms) was essentially simultaneous with the onset of visual cortical processing, as indexed by the onset of the visual C1 component, which is thought to represent the earliest cortical visual evoked potential. The coincident timing of the early AV interaction and C1 strongly suggests that AV interactions can affect early visual sensory processing. Additional AV interactions were found within the time course of sensory processing (up to 200 ms post stimulus onset). In total, this system of AV effects over the scalp was suggestive of both activity unique to multisensory processing, and the modulation of 'unisensory' activity. RTs to the stimuli when presented simultaneously were significantly faster than when they were presented alone. This RT facilitation could not be accounted for by probability summation, as evidenced by violation of the 'race' model, providing compelling evidence that auditory-visual neural interactions give rise to this RT effect.
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Author information
Author/s: Molholm, Sophie (S); Ritter, Walter (W); Murray, Micah M (MM); Javitt, Daniel C (DC); Schroeder, Charles E (CE); Foxe, John J (JJ);
Affiliation: Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.
Grants: MH61989 (Agency:United States NIMH) ; MH63434 (Agency:United States NIMH) ; NS30029-23 (Agency:United States NINDS) ; R01 MH065350-01A2 (Agency:United States NIMH)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: Brain research. Cognitive brain research (Brain Res Cogn Brain Res), published in Netherlands. (Language: eng)
Reference: 2002-Jun; vol 14 (issue 1) : pp 115-28
Dates: Created 2002/06/13; Completed 2003/01/02; Revised 2007/11/14;
PMID: 12063135, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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