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| Research article summary (published 30 Jul 2002): |
Multicenter P300 brain mapping of impaired attention to cues in hyperkinetic children.
Full Abstract
OBJECTIVE:
To measure specific neurophysiological attention deficits in children with hyperkinetic disorders (HD; the ICD-10 diagnosis for severe and pervasive attention-deficit/hyperactivity disorder [ADHD]).
METHOD:
In a multicenter sample of 148 children with HD and control children aged 8 to 14 years, event-related potential maps were recorded during a cued continuous performance test (A-X/O-X). Maps to cues (requiring attention but no response) and distractors and performance were tested for differences between age- and sex-matched HD and control groups (n = 57 each), as well as between clinics (n = 5).
RESULTS:
The N1, P3a, and P3b maps revealed reliable attention effects, with larger amplitudes after cues than after distractors, and only minor differences across clinics. Children with HD missed more targets, made more false alarms, and had larger N1 followed by smaller P3b amplitudes after cues than did controls. Cue-P3b amplitude correlated with detecting subsequent targets. Cue-P3b tomography indicated posterior sources that were attenuated in children with HD.
CONCLUSIONS:
Brain mapping indicates that children with HD attend to cues (preceding potential targets) with increased initial orienting (N1) followed by insufficient resource allocation (P3b). These multiple, condition-specific attention deficits in HD within 300 msec extend previous results on ADHD and underline the importance of high temporal resolution in mapping severe attention deficits.
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Author information
Author/s: Brandeis, Daniel (D); Banaschewski, Tobias (T); Baving, Lioba (L); Georgiewa, Petra (P); Blanz, Bernhard (B); Warnke, Andreas (A); Steinhausen, Hans-Christoph (HC); Rothenberger, Aribert (A); Scheuerpflug, Peter (P);
Affiliation: Department of Child and Adolescent Psychiatry, University of Zürich, Switzerland. brandeis(-atsign-)kjpd.unizh.ch
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Journal of the American Academy of Child and Adolescent Psychiatry (J Am Acad Child Adolesc Psychiatry), published in United States. (Language: eng)
Reference: 2002-Aug; vol 41 (issue 8) : pp 990-8
Dates: Created 2002/08/06; Completed 2002/09/06; Revised 2006/11/15;
PMID: 12162635, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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