 |
| Research article summary (published 6 Apr 2003): |
MRS in relation to hippocampal volume in the oldest old.
Full Abstract
The MRS brain metabolite ratio N-acetylaspartate (NAA)/myo-inositol (mI) is reported to be decreased in AD. MRS was used to study medial temporal and parietal regions in 60 cognitively healthy subjects older than 85 years. Subjects with small hippocampal volumes, a putative risk factor for dementia, had significantly lower NAA/mI in parietal and temporal lobes compared with other subjects. Neuropsychological tests and APOE genotype did not correlate with MRS ratios. MRS measures are candidate biomarkers for dementia risk.
Learn Faster Today Improve your study skills
Author information
Author/s: Spencer, David C (DC); Zitzelberger, Tracy (T); Spielman, Daniel (D); Kaye, Jeffrey (J);
Affiliation: Oregon Health & Science University, Department of Neurology, Portland, OR 97201, USA. spencerd(-atsign-)ohsu.edu
Grants: AG 08017 (Agency:United States NIA)
Journal and publication information
Publication Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Neurology (Neurology), published in United States. (Language: eng)
Reference: 2003-Apr; vol 60 (issue 7) : pp 1194-6
Dates: Created 2003/04/08; Completed 2003/04/23; Revised 2007/11/14;
PMID: 12682335, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.