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| Research article summary (published 27 Feb 2002): |
Motor response to apomorphine in patients with Parkinson's disease with long-duration response to levodopa.
Full Abstract
The authors studied the motor response to apomorphine before and 1 year after levodopa therapy in 12 patients with Parkinson's disease. At the 1-year evaluation, the basal tapping score, recorded after a 12-hour levodopa withdrawal, was higher compared with the test performed while patients were de novo, indicating the presence of a long-duration response to levodopa. The amplitude (net increase) of the motor response to apomorphine was similar before and during levodopa therapy. However, because of the better baseline, the maximal tapping score was higher during levodopa therapy. The duration and the latency of the motor response to apomorphine did not change. The presence of a short-duration response to apomorphine, in the presence of a long-duration response to levodopa, may imply that either different compartment (i.e., postsynaptic versus presynaptic) or transduction pathways are involved in such responses.
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Author information
Author/s: Bonuccelli, Ubaldo (U); Napolitano, Alessandro (A); Del Dotto, Paolo (P); Quattrone, Aldo (A);
Affiliation: Department of Neuroscience, University of Pisa, Pisa, Italy.
Journal and publication information
Publication Type: Clinical Trial; Comparative Study; Journal Article
Journal: Clinical neuropharmacology (Clin Neuropharmacol), published in United States. (Language: eng)
Reference: -2002 Mar-Apr; vol 25 (issue 2) : pp 119-21
Dates: Created 2002/04/30; Completed 2002/06/24; Revised 2006/11/15;
PMID: 11981241, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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